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Research

Read the Research Product Sharing Plan

Watch the first webinar Introducing the MSCollaboratory

In this webinar hosted by the Gordon and Betty Moore Foundation on Feb 20, 2024 we highlighted how the project will contribute to your research by providing trainings and resources to apply mass spectrometry-based approaches that will facilitate the understanding of your system at the molecular level.

Submitted MassIVE Datasets

Visit the  MassIVE repository (filtered by "mscollaboratory" under keywords) to access the datasets collected under the MSCollaboratory initiative. 

The undiscovered natural product potential of Actinomycetes

https://www.nature.com/articles/s41429-025-00876-x

With our LC-MS/MS-based approach we provide further evidence of the potential that Actinomycetes have to produce small molecules.

Some key messages from this piece of work:

  • This is a large dataset of untargeted liquid chromatography tandem mass spectrometry (LC-MS/MS) from 948 microbial strains, already part of microbeMASST
  • The dataset is publicly available to the scientific community
  • Our analysis provides evidence of the vast potential of discovery of microbial molecules (see Fig 2)
  • We applied the latest computational approaches in the field of metabolomics to provide curated annotation of microbial molecules (some of you are familiar with the lack of reference spectra for identification of molecules), a great contribution to the CMMC knowledgebase
  • We provide use of the dataset to highlight its value for discovery of microbial molecules by demonstrating the detection of recently discovered non-ribosomal peptides and analogues.

This work also provided the opportunity for learning, training (e.g., culturing techniques, sample preparation, data acquisition, data analysis) and applying untargeted metabolomics approaches by undergrads, grads, postdocs and visiting scholars, in line with the goals of the MSCollaboratory.  

Wonderful and collaborative work, thank you all the co-authors 

 And wait for more exciting research outcomes here!

 Accelerating Metabolomic Analysis of Aquatic Symbioses